परेशान होना  =  be annoyed
I've had it with your constant arguing! shut up, both of you!

बहुत थका हुआ होना  =  be extremely tired
I've had it! i must get some sleep.

बहुत ही बदतर हालत में होना  =  be in a bad condition
Let's be honest, the car's had it -we need a new one./he felt so ill that he was sure he'd had it.

खैर नहीं होना  =  experience unplesant
My father saw you scratch his car- you've had it now!